Below are print-friendly
files offered in Portable Document Format. Click on highlighted text to
How to view PDF
files // View
the Entire December 2001 Issue in PDF (9.8MB)
Simulation-Aided Design of microfluidic Devices
devices are chip-based systems used for processing and analyzing fluids
and their constituents. Fabricated with the same lithographic techniques
used for microelectronics, the devices integrate sensors, actuators, and
other electromechanical components to move fluids through a maze of microscopic
channels and chambers. A Lawrence Livermore team is developing a complex,
three-dimensional simulation capability to help guide the design of microfluidic
devices. The teams computer code provides, for the first time, an
accurate representation of the behavior of suspended particles, especially
polystyrene beads and biological macromolecules, as they travel inside
a microfluidic device. The simulation capability incorporates channel
complexities and such parameters as fluid flow rates, particle interactions,
and external forces. The team is working for the Defense Advanced Research
Projects Agency (DARPA), the advanced research arm of the Department of
Defense. DARPA is developing microfluidic devices called BioFlips (for
BioFluidic Chips) for detecting biological macromolecules and microbes
if used in biowarfare.
Small Science Gets to the Heart of Matter
on almost the smallest possible scale, Livermore scientists are examining
how materials are organized on surfaces and are conducting their examinations
on an atom-by-atom and molecule-by-molecule basis. They are learning how
the organization affects the materials properties. At this nanometer
scale, the scientists need to use only the most powerful imaging tools.
Thus, they are making the atomic force microscope more sensitive and developing
new imaging methods, including the confocal microscope and surface-enhanced
Raman spectroscopy. The goal for these imaging tools is to identify single
molecules. The scientists are also working with molecular templates that
can be used to develop sensors to detect biological and chemical warfare
agents, to enhance protein crystallography, and to test corrosion resistance.
Other projects are mimicking the natural growth of calcium-based structures.
Technology to Help Diabetics
device that continuously monitors blood glucose will make it easier for
diabetics to manage their disease.
| S&TR Home | LLNL
Home | Help
| Phone Book | Comments
Site designed and maintained by Kitty
Lawrence Livermore National Laboratory
Operated by the University of California for the U.S.
Department of Energy
January 25, 2001